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KMID : 0604520060320010035
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Journal of the Society of Cosmetic Scientists of Korea
2006 Volume.32 No. 1 p.35 ~ p.44
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Preparation and Evaluation of Poly(methylmethacrylate-co-trimethoxysilylpropylmethacrylate) Spheres Containing Whitening and Anti-wrinkle Agents
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Jung Taek-Kyu
Lim Mi-Sun
Kim Young-Baek
Yoon Kyung-Sup
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Abstract
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Recently, encapsulation studies have been tarried out to protect active agents using shell materials such as polymers, lipids, inorganic materials and the other protective materials. We have prepared copolymers of methylmethacrylate (MMA) and trimethoxysilylpropylmethacrylate (TMPMA), and the copolymers as shell materials were used for encapsulating active agents. Poly(MMA-co-TMPMA) spheres were very efficient for encapsulating active agents such as vitamin derivatives (such as retinol, retinyl palmitate, tocopheryl acetate and ascorbyl tetraisopalmitate) and oil soluble licorice extract etc. Mean diameters of poly(MMA-co-TMPMA) core-shell spheres containing active agents varied between about 0.1 to 10{mu}m according to the experimental conditions. The loading amount of encapsulating active agents was 15 to 25% (w/w) and the loading yield was above 90%. The stability of active agents in poly(MMA-co-TMPMA) core-shell spheres prepared with an UV absorbing precursor increased by 25% compared with that of active agents in spheres prepared without an UV absorbing precursor.
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KEYWORD
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encapsulating, active agents, methylmethacrylate (MMA), trimethoxysilylpropylmethacrylate (TMPMA), UV absorbing precursor
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